基本信息：

陈应庄，1982年7月生，籍贯湖南省长沙市，汉族。

2001年-2005年在烟台大学学习并获得生物技术专业学士学位。

2005-2008年在湖南师范大学学习并获得药物分析学硕士学位。

2008-2012年在湖南大学学习并获得分析化学中药现代化方向博士学位。

2012年9月起在湖南师范大学任教至今，期间于2018.5-2019.5在德国杜伊斯堡-埃森大学进行为期一年的公派访学研究。

 

 

研究方向：

1.天然产物快速分离纯化技术研究。

2.色谱分离机理以及微柱分离材料制备与应用。

3.全二维液相色谱新技术研究与应用。

 

 

获批基金项目：

1. 双水相接枝共聚“一锅法”合成糖基化整体柱及其在蛋白质组学中的应用(21305040)，国家自然科学基金，项目负责人：陈应庄，2014.01-2016.12，结题。

2. 新型温敏杂化整体材料制备及其在蛋白疏水分离中的应用（14JJ7034），省、市、自治区科技项目，项目负责人：陈应庄，2014.01-2016.12，结题

3. 基于开管整体柱的全二维液相色谱系统的构建及其在复杂体系分析中应用（2018JJ2251），省、市、自治区科技项目，项目负责人：陈应庄，2018.01-2020.12，在研

4. 建立基于烟叶原料中与品质相关关键化学成份的感官品质快速评价方法，企业开放基金，项目负责人：陈应庄，2018.01-2020.12，在研。

 

 

文章发表：

2020年发表文章

1. Hu Deping^#, Li Yuandong ^#, Zhao Hui, Zhao Yang, Huang Si, Li Juan, Li Zhenjie, Duan Yuanxing, Yingzhuang Chen*, Jianjun Xia*, On-line high pH-reversed phase liquid chromatography×low pH-reversed phase liquid chromatography tandem electrospray ionization mass spectrometry combined with pulse elution gradient in the first dimension for the analysis of alkaloids in Macleaya cordata(willd.)R. Br. Journal of Separation Science, 2020, https://doi.org /10.1002/jssc. 201900950.

2. Tan Wangming#, Chen Ye#, Xiong Xiyue, Huang Si, Fang Zhengfa, Chen Yingzhuang*, Ma Ming, Chen Bo. Synthesis of a ploy( sulfobetaine -co- polyhedral oligomeric silsesquioxane) hybrid monolith via an in-situ ring opening quaternization for use in hydrophilic interaction capillary liquid chromatography. Microchimica Acta, 2020, 187, 109. https://doi.org/10.1007/s00604-019-4088-z.

3. Chen Yingzhuang, Montero Lidia, Luo Jiang, Li Junjie, Schmitz J. Oliver*. Application of the new at-column dilution (ACD) modulator for the two-dimensional RP×HILIC analysis of Buddleja davidii. Analytical and Bioanalytical Chemistry, 2020, https://doi.org/10.1007/s00216-020-02392-3.

 

2019年发表文章

1. Yingzhuang Chen^#, Junjie Li^#, Oliver J. Schmitz*, Development of an at-Column dilution modulator for flexible and precise control of dilution factors to overcome mobile phase incompatibility in comprehensive two-dimensional liquid chromatography, Analytical Chemistry, 2019, 91, 10251-10257.

2. Yingzhuang Chen, Lidia Montero, and Oliver J. Schmitz*. Advance in on-line two-dimensional liquid chromatography modulation technology. Trends in Analytical Chemistry. 2019, 120,115647.

3. Yingzhuang Chen*, Yajun Wu, Xiaoming Liu, Bowen Li, Deping Hu, Si Huang, Ming Ma, Bo Chen, Pulsed elution modulation for on-line comprehensive two-dimensional liquid chromatography coupling reversed phase liquid chromatography and hydrophilic interaction chromatography. Journal of Chromatography A, 2019,1583, 98-107.

4. Chang Feng, Yue Yunfang, Yang Zihui, Huang Si, Liu Zhihua, Wang Kunmiao, Peng Yan, Chen Yingzhuang*, Ma Ming, Chen Bo, The fabrication of poly (polyethylene glycol diacrylate) monolithic porous layer open tubular (mono‐PLOT) columns and applications in hydrophilic interaction chromatography and capillary gas chromatography for small molecules. Electrophoresis, 2019, 40, 521-529.

 

2017年发表文章

1. Chen Ye, Shu Yan, Yang Zihui, Lv Xumei, Tan Wangming, Chen, Yingzhuang*, Ma Ming, Chen Bo, The preparation of a poly (pentaerythritol tetraglycidyl ether- co -poly ethylene imine) organic monolithic capillary column and its application in hydrophilic interaction chromatography for polar molecules. Analytica Chimica Acta, 2017, 988,104-113.

2. Tan Wangming, Chang Feng, Shu Yan, Chen Ye, Liu Jingjing, Chen Yingzhuang*, Ma Ming, Chen Bo，The synthesis of Gemini-type sulfobetaine based hybrid monolith and its application in hydrophilic interaction chromatography for small polar molecular. Talanta，2017, 173,113-122.

3. Zeng Jiao, Liu Shengquan, Wang Menglin, Yao Shouzhuo*, Chen Yingzhuang *. The synthesis of weak acidic type hybrid monolith via thiol-ene click chemistry and its application in hydrophilic interaction chromatography. Electrophoresis, 2017, 38, 1325–1333.

4. Wu Yajun, Liu Jingjing, Gu Su, Lin Li, Chen Yingzhuang*, Ma Ming, Chen Bo, Orthogonal strategy development using reversed macroporous resin coupled with hydrophilic interaction liquid chromatography for the separation of Ginsenosides from Ginseng Root Extract. Journal of Separation Science, 2017, 40, 4128–4134.

 

2016年发表文章

1. Xiong Xiyue, He Haiqin，Shu Yan, Li Yuxin, Yang Zihui，Chen Yingzhuang*，Ma Ming, Chen Bo*, The synthesis of surface-glycosylated porous monolithic column via aqueous two-phase graft copolymerization and its application in capillary-liquid chromatography. Talanta，2016，161, 721-729.

2. Lv Xumei, Tan Wangming, Chen Ye, Chen Yingzhuang*, Ma Ming, Chen Bo*, Facile "one-pot" synthesis of poly(methacrylic acid)-based hybrid monolith via thiol-ene click reaction for hydrophilic interaction chromatography, Journal of Chromatography A，2016, 1454, 49-57.

 

2014年以前发表文章

1. 熊喜悦，彭泽强，舒彦，何海琴，陈应庄*，陈波，巯-烯点击反应在毛细管整体柱制备中的应用，化学进展，2014.01.01，（01）, 152~157.

2. Chen, Yingzhuang，Wang, Keyi，Liu, Yixuan，Yang, Huihui，Yao, Shouzhuo*，Chen, Bo，Nie, Lihua，Xu, Guangming Improved sulfoalkylbetaine-based organic-silica hybrid monolith for high efficient hydrophilic interaction liquid chromatography of polar compounds，Eletrophoresis，2013, 34, 1877~1885.

3. Chen, Yingzhuang，Wang, Keyi，Yang, Huihui，Liu, Yixuan，Yao, Shouzhuo*，Chen, Bo，Nie, Lihua，Xu, Guangming. synthesis of sulfo/vinyl biphasic silica hybrid monolithic capillary column and its application to on-columnpreconcentration for capillary electrochromatography，Journal of Chromatography A，2012，1233, 91~99.

4. Chen, Yingzhuang，Wu, Minghuo，Wang, Keyi，Chen, Bo，Yao, Shouzhuo*， Zou, Hanfa*，Nie, Lihua，Vinyl functionalized silica hybrid monolith-based trypsin microreactor for on line digestion and separation via thiol-ene "click" strategy，Journal of ChromatographyA，2011，1218, 7982~7988.

5. Chen, Yingzhuang，Liu, Guo-Zhu，Shen, Yao，Chen, Bo*，Zeng, Jianguo*， Analysis of alkaloids in Macleaya cordata (Willd.) R. Br. using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry，Journal of Chromatography A，2009，1216, 2104~2110.

 

 

研究成果：

-       授权专利  

1.陈应庄，排名：1，装柱装置及装柱系统，ZL 201510245419.8，国家发明专利，2018-06-26

2.陈应庄，排名：1，层析装置，ZL 201510279066.3，国家发明专利，2016-10-26

3.陈应庄，排名：1，溶剂接收循环装置及包含该溶剂接收循环装置的层析装置，ZL201510279036.2,国家发明专利，2016-11-09

4.陈应庄，排名：1/9，层析装置，ZL 201410298303.6，国家发明专利，2015-09-16

5.陈应庄，排名：1，甜菜碱型整体柱及其制备方法，ZL 201611074463.8，国家发明专利，2019-11-27

6.陈应庄，排名：1，多维色谱系统，ZL 201710792504.5，国家发明专利，2017-09-05

7.陈应庄，排名：1，多维色谱系统及多维色谱分离方法，ZL 201910283021.1，国家发明专利，2020-04-08

 

 

 

联系方式：

yingzhuangchen2012@163.com  

 

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